Fighting Cancer Cells with the Cabbage Butterfly

Adult butterflies differ from their larvae (caterpillars) in both appearance and diet. While the larvae crawl around and eat leaves, adult butterflies are colorful, have wings, and fly from flower to flower, eating nectar. These changes occur during the periods when the larva is preparing to become a pupa and when the pupa is preparing to become an adult. So what exactly happens inside the pupa’s body during these times? Its body destroys the cells from organs that will be unnecessary to the adult butterfly, and creates cells for the new organs that will be necessary. Researchers have discovered that the pupa secretes a substance called pierisin into its body fluid, which destroys unnecessary cells while leaving important ones unharmed.

Form/Organization/System:: Decomposition

Defense/Stability:: Living tissue control

Other

Sugimura T. Butterflies, Cancer, the Unknown and Me.

Cancer-fighting drugs currently in use today have the unfortunate side effect of attacking healthy cells as well as cancerous ones, placing a huge burden on the body of the patient. Researchers have successfully used the piersin-containing body fluid of butterfly pupae to kill stomach cancer cells. Piersin could play a major role in developing cancer treatments with few or no side effects if researchers can learn how to use it to destroy only targeted cancer cells while leaving healthy cells intact.

Query	Affected	Num. rows	Took (ms)	Actions
SHOW FULL COLUMNS FROM `contents`	16	16	2	maybe slow
SELECT CHARACTER_SET_NAME FROM INFORMATION_SCHEMA.COLLATIONS WHERE COLLATION_NAME= 'utf8_general_ci';	1	1	1
SHOW FULL COLUMNS FROM `users`	10	10	1	maybe slow
SHOW FULL COLUMNS FROM `groups`	4	4	1	maybe slow
SHOW FULL COLUMNS FROM `permissions`	5	5	1	maybe slow
SHOW FULL COLUMNS FROM `groups_permissions`	3	3	1	maybe slow
SHOW FULL COLUMNS FROM `groups_users`	3	3	1	maybe slow
SHOW FULL COLUMNS FROM `contents_searches`	6	6	1	maybe slow
SHOW FULL COLUMNS FROM `attachments`	11	11	1	maybe slow
SHOW FULL COLUMNS FROM `attachments_revs`	13	13	1	maybe slow
SHOW FULL COLUMNS FROM `contents_related_items`	5	5	1	maybe slow
SHOW FULL COLUMNS FROM `related_items`	6	6	1	maybe slow
SHOW FULL COLUMNS FROM `contents_related_items_revs`	8	8	1	maybe slow
SHOW FULL COLUMNS FROM `contents_tags`	5	5	1	maybe slow
SHOW FULL COLUMNS FROM `tags`	7	7	1	maybe slow
SHOW FULL COLUMNS FROM `tag_groups`	6	6	1	maybe slow
SHOW FULL COLUMNS FROM `contents_tags_revs`	7	7	1	maybe slow
SHOW FULL COLUMNS FROM `contents_revs`	18	18	2	maybe slow
SELECT `Content`.`id`, `Content`.`user_id`, `Content`.`last_edit_user_id`, `Content`.`post_date`, `Content`.`post_date_year`, `Content`.`post_date_month`, `Content`.`post_date_day`, `Content`.`title`, `Content`.`title_en`, `Content`.`content`, `Content`.`plain_content`, `Content`.`page_view`, `Content`.`flag`, `Content`.`mod_count`, `Content`.`created`, `Content`.`modified` FROM `contents` AS `Content` WHERE `id` = 172 LIMIT 1	1	1	0
SELECT `Attachment`.`file_name`, `Attachment`.`dir`, `Attachment`.`model`, `Attachment`.`foreign_key` FROM `attachments` AS `Attachment` WHERE `file_name` <> 'default.jpg' AND `Attachment`.`foreign_key` = (172)	1	1	0
SELECT `ContentsRelatedItem`.`content`, `ContentsRelatedItem`.`related_item_id`, `ContentsRelatedItem`.`content_id` FROM `contents_related_items` AS `ContentsRelatedItem` WHERE `ContentsRelatedItem`.`content_id` = (172)	11	11	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 1	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 2	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 4	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 6	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 7	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 8	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 9	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 9	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 9	1	1	0
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 11	1	1	8	maybe slow
SELECT `RelatedItem`.`code`, `RelatedItem`.`name` FROM `related_items` AS `RelatedItem` WHERE `RelatedItem`.`id` = 12	1	1	0
SELECT `ContentsTag`.`id`, `ContentsTag`.`tag_group_id`, `ContentsTag`.`mod_count`, `ContentsTag`.`tag_id`, `ContentsTag`.`content_id` FROM `contents_tags` AS `ContentsTag` WHERE `ContentsTag`.`content_id` = (172)	3	3	0
SELECT `Tag`.`name`, `Tag`.`comment`, `Tag`.`tag_group_id` FROM `tags` AS `Tag` WHERE `Tag`.`id` = 51	1	1	0
SELECT `TagGroup`.`code`, `TagGroup`.`name` FROM `tag_groups` AS `TagGroup` WHERE `TagGroup`.`id` = 4	1	1	0
SELECT `Tag`.`name`, `Tag`.`comment`, `Tag`.`tag_group_id` FROM `tags` AS `Tag` WHERE `Tag`.`id` = 84	1	1	0
SELECT `TagGroup`.`code`, `TagGroup`.`name` FROM `tag_groups` AS `TagGroup` WHERE `TagGroup`.`id` = 6	1	1	0
SELECT `Tag`.`name`, `Tag`.`comment`, `Tag`.`tag_group_id` FROM `tags` AS `Tag` WHERE `Tag`.`id` = 175	1	1	0
SELECT `TagGroup`.`code`, `TagGroup`.`name` FROM `tag_groups` AS `TagGroup` WHERE `TagGroup`.`id` = 7	1	1	0
SELECT `RelatedItem`.`id`, `RelatedItem`.`code`, `RelatedItem`.`name`, `RelatedItem`.`created`, `RelatedItem`.`modified`, `RelatedItem`.`flag` FROM `related_items` AS `RelatedItem` WHERE `code` = 'function' LIMIT 1	1	1	0
SELECT `Content`.`id`, `Content`.`title`, `Content`.`title_en` FROM `contents` AS `Content` WHERE id = (NULL) ORDER BY `id` desc	0	0	0

Message	Memory use
Component intitailization	6.79 MB
Controller action start	6.83 MB
Controller render start	6.90 MB
View render complete	7.92 MB

Message	Time in ms	Graph
Core Processing (Derived)	346.00
Component initialization and startup	16.68
Controller action	47.70
Render Controller Action	61.84
» Rendering View	50.01
» » Rendering APP/views/contents/view.ctp	37.80
» » Rendering APP/views/layouts/default.ctp	10.42
» » » Rendering APP/views/elements/header.ctp	1.54
» » » Rendering APP/views/elements/content_sidebar.ctp	0.33
» » » Rendering APP/views/elements/footer.ctp	0.43

Fighting Cancer Cells with the Cabbage Butterfly

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Fighting Cancer Cells with the Cabbage Butterfly

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